Who should not take Augmentin
A contraindication is a condition under which Augmentin (Amoxicillin/Clavulanate) should not be taken because the risk outweighs the benefit. Augmentin has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 500/125mg, 875/125mg, 1000/62.5mg dosing range.
Absolute contraindications
According to the prescribing information for Amoxicillin, Clavulanate, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Augmentin can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), but is hydrolysed by beta-lactamase enzymes produced by some resistant bacteria.
Frequently asked questions
Can someone with heart disease take Augmentin? ▾
Some forms of heart disease are absolute contraindications for Augmentin, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Augmentin use under specialist supervision. The prescribing information for Amoxicillin, Clavulanate should be reviewed.
Is Augmentin safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Augmentin at adjusted lower 500/125mg, 875/125mg, 1000/62.5mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Augmentin
- With alcoholAugmentin and alcohol — is it safe to drink?
- With foodShould Augmentin be taken with food?
- Side effectsAugmentin side effects: common, rare and warning signs
- Dosage guideAugmentin dosage guide: how much to take and when
- OnsetHow fast does Augmentin start working?
- DurationHow long does Augmentin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.