Second-generation H1 antihistamine
The Second-generation H1 antihistamine class covers 3 of the active ingredients in this catalogue, including Cetirizine, Fexofenadine, Loratadine. Ingredients in one class share a mechanism of action, so their interactions, contraindications and typical side effects tend to overlap.
Active ingredients
- R06AE07CetirizineSecond-generation H1 antihistamine
Cetirizine is a second-generation H1 antihistamine used in adults and children for allergic rhinitis, conjunctivitis and chronic urticaria. It blocks peripheral H1 histamine receptors with limited central penetration and modest sedation.
- R06AX26FexofenadineSecond-generation H1 antihistamine
Fexofenadine is a second-generation H1 antihistamine used in adults and children for allergic rhinitis and urticaria. It is the active metabolite of terfenadine and produces minimal central nervous system penetration with no clinically relevant sedation.
- R06AX13LoratadineSecond-generation H1 antihistamine
Loratadine is a second-generation H1 antihistamine used in adults and children for allergic rhinitis and urticaria. It blocks peripheral H1 receptors with very limited central penetration, supporting once-daily dosing with minimal sedation.
Medications
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AllegraFexofenadine30mg · 60mg · 120mg · 180mg -
ClaritinLoratadine5mg · 10mg -
ZyrtecCetirizine5mg · 10mg
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