Restoril vs Desyrel: side-by-side comparison
Restoril (Sleep Aids and Hypnotics) and Desyrel (Anti-Depressants) belong to different therapeutic classes and are rarely interchangeable. This page compares the medications' purposes, mechanisms and the situations where each is used.
| Property | Restoril | Desyrel |
|---|---|---|
| Active ingredient | Temazepam | Trazodone |
| Manufacturer | Mallinckrodt | Various generics |
| Class | Sleep Aids and Hypnotics | Anti-Depressants |
| Strengths | 7.5mg, 15mg, 22.5mg, 30mg | 50mg, 100mg, 150mg, 300mg |
| Forms | capsule | tablet |
What's the same
Restoril and Desyrel are used in very different patients, and the points in common are limited. The main shared element is that both meet regulatory standards for efficacy and safety and benefit from pharmacist oversight.
Key differences
Restoril belongs to Sleep Aids and Hypnotics while Desyrel belongs to Anti-Depressants. Indications, mechanisms and target populations differ. The comparison is most useful when a clinician has mentioned both medications and the patient wants to understand where each fits.
Mechanism and action
Restoril: Temazepam binds the benzodiazepine site of the GABA-A receptor and allosterically enhances inhibitory chloride conductance. Desyrel: Trazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI).
When Restoril is preferred
Restoril is approved in adults for the short-term treatment of insomnia, particularly when difficulty maintaining sleep is prominent.
When Desyrel is preferred
Desyrel (trazodone) is approved for major depressive disorder.
Frequently asked questions
Is Restoril or Desyrel better? ▾
Restoril and Desyrel are not interchangeable — they treat different conditions. Asking which is "better" is meaningful only when a clinician has weighed both for the same specific clinical scenario.
Can I switch from Restoril to Desyrel? ▾
Switching between Restoril and Desyrel is rarely an appropriate decision since they belong to different classes and treat different conditions. The real question is usually whether the diagnosis calls for one medication or the other — which the prescriber resolves.
Do Restoril and Desyrel have the same side effects? ▾
No — they belong to different classes and have distinct side-effect profiles. Each medication has its own prescribing information.
More Restoril comparisons
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.