Restoril vs Lunesta: side-by-side comparison
Restoril (Temazepam) and Lunesta (Eszopiclone) both belong to the Sleep Aids and Hypnotics class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Restoril | Lunesta |
|---|---|---|
| Active ingredient | Temazepam | Eszopiclone |
| Manufacturer | Mallinckrodt | Sunovion |
| Class | Sleep Aids and Hypnotics | Sleep Aids and Hypnotics |
| Strengths | 7.5mg, 15mg, 22.5mg, 30mg | 1mg, 2mg, 3mg |
| Forms | capsule | tablet |
What's the same
Restoril and Lunesta both belong to the Sleep Aids and Hypnotics class and are used for partially overlapping indications. The active ingredients — Temazepam vs Eszopiclone — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Temazepam vs Eszopiclone), strengths (7.5mg, 15mg, 22.5mg, 30mg vs 1mg, 2mg, 3mg), forms (capsule vs tablet), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Restoril: Temazepam binds the benzodiazepine site of the GABA-A receptor and allosterically enhances inhibitory chloride conductance. Lunesta: Eszopiclone is a positive allosteric modulator of the GABA-A receptor at a site close to the benzodiazepine binding site.
When Restoril is preferred
Restoril is approved in adults for the short-term treatment of insomnia, particularly when difficulty maintaining sleep is prominent.
When Lunesta is preferred
Lunesta is approved in adults for the treatment of insomnia, including difficulty falling asleep and difficulty maintaining sleep.
Frequently asked questions
Is Restoril or Lunesta better? ▾
There is no single answer. Restoril and Lunesta both belong to the Sleep Aids and Hypnotics class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Restoril to Lunesta? ▾
Switching within the Sleep Aids and Hypnotics class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Restoril and Lunesta have the same side effects? ▾
They share many of the Sleep Aids and Hypnotics class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
More Restoril comparisons
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.