Sertraline vs Trazodone: side-by-side comparison
Sertraline (Selective serotonin reuptake inhibitor (SSRI)) and Trazodone (Atypical antidepressant / serotonin modulator) belong to different therapeutic classes and are rarely substitutes for each other. The comparison is useful when a single patient is weighing both options for adjacent or overlapping needs.
| Property | Sertraline | Trazodone |
|---|---|---|
| Therapeutic class | Selective serotonin reuptake inhibitor (SSRI) | Atypical antidepressant / serotonin modulator |
| CAS | 79617-96-2 | 19794-93-5 |
| ATC | N06AB06 | N06AX05 |
| Molecular weight | 306.2 g/mol | 371.86 g/mol |
| Brands with this active ingredient | 2 | 1 |
What they share
Sertraline and Trazodone share the common regulatory framework for prescription active ingredients, bioequivalence standards for generics, and pharmacist oversight. Beyond that, points in common are limited.
Key differences
Sertraline acts by a different mechanism than Trazodone, with indications that barely overlap. Comparing the two is useful when a clinician has mentioned both in the same context or the patient wants to understand why one was prescribed instead of the other.
Mechanisms compared
Sertraline: Sertraline selectively blocks the reuptake of serotonin (5-HT) by the presynaptic neuron, increasing the concentration of serotonin in the synaptic cleft. Trazodone: Trazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI).
Indications compared
Sertraline: Sertraline is approved for several psychiatric indications in adults: major depressive disorder, panic disorder with or without agoraphobia, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), soc… Trazodone: Trazodone is approved for major depressive disorder.
Safety profile
Sertraline: Common adverse effects include nausea, diarrhoea, insomnia, sexual dysfunction, dry mouth and sweating, particularly during the first weeks of treatment. Trazodone: Common adverse effects are sedation (the desired effect at low doses), dry mouth, dizziness, orthostatic hypotension and headache.
Frequently asked questions
Is Sertraline better than Trazodone? ▾
Sertraline and Trazodone are not "better or worse" — they treat different things. The sensible question is which fits your specific need.
Can Sertraline and Trazodone be combined? ▾
Whether they can be combined depends on the indications and the interaction profile of each. If both are in a single prescription, the prescriber has weighed it; in self-medication they should never be combined.
Do they have the same side-effect profile? ▾
No — they belong to different classes and have distinct side-effect profiles. Each has its own prescribing information.
Products with Sertraline
Products with Trazodone
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.