Amlodipine vs Duloxetine: side-by-side comparison
Amlodipine (Dihydropyridine calcium-channel blocker) and Duloxetine (Serotonin-norepinephrine reuptake inhibitor (SNRI)) belong to different therapeutic classes and are rarely substitutes for each other. The comparison is useful when a single patient is weighing both options for adjacent or overlapping needs.
| Property | Amlodipine | Duloxetine |
|---|---|---|
| Therapeutic class | Dihydropyridine calcium-channel blocker | Serotonin-norepinephrine reuptake inhibitor (SNRI) |
| CAS | 88150-42-9 | 116539-59-4 |
| ATC | C08CA01 | N06AX21 |
| Molecular weight | 408.88 g/mol | 297.41 g/mol |
| Brands with this active ingredient | 1 | 1 |
What they share
Amlodipine and Duloxetine share the common regulatory framework for prescription active ingredients, bioequivalence standards for generics, and pharmacist oversight. Beyond that, points in common are limited.
Key differences
Amlodipine acts by a different mechanism than Duloxetine, with indications that barely overlap. Comparing the two is useful when a clinician has mentioned both in the same context or the patient wants to understand why one was prescribed instead of the other.
Mechanisms compared
Amlodipine: Amlodipine selectively blocks L-type calcium channels in vascular smooth muscle, reducing transmembrane calcium influx and producing peripheral arterial vasodilation. Duloxetine: Duloxetine inhibits the reuptake of both serotonin and norepinephrine at the synapse, with weaker effect on dopamine.
Indications compared
Amlodipine: Amlodipine is approved in adults for the treatment of essential hypertension and chronic stable angina, and for vasospastic (Prinzmetal's) angina. Duloxetine: Duloxetine is approved for major depressive disorder, generalised anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal pain (back pain, osteoarthritis) and stress urinary incontin…
Safety profile
Amlodipine: Common adverse effects include peripheral oedema (typically ankle), flushing, headache, palpitations and fatigue, mostly dose-related. Duloxetine: Common adverse effects include nausea (most prominent in the first 1–2 weeks), dry mouth, headache, fatigue, sleep disturbance and sexual dysfunction.
Frequently asked questions
Is Amlodipine better than Duloxetine? ▾
Amlodipine and Duloxetine are not "better or worse" — they treat different things. The sensible question is which fits your specific need.
Can Amlodipine and Duloxetine be combined? ▾
Whether they can be combined depends on the indications and the interaction profile of each. If both are in a single prescription, the prescriber has weighed it; in self-medication they should never be combined.
Do they have the same side-effect profile? ▾
No — they belong to different classes and have distinct side-effect profiles. Each has its own prescribing information.
Products with Amlodipine
Products with Duloxetine
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.