Amlodipine vs Amitriptyline: side-by-side comparison
Amlodipine (Dihydropyridine calcium-channel blocker) and Amitriptyline (Tricyclic antidepressant (TCA)) belong to different therapeutic classes and are rarely substitutes for each other. The comparison is useful when a single patient is weighing both options for adjacent or overlapping needs.
| Property | Amlodipine | Amitriptyline |
|---|---|---|
| Therapeutic class | Dihydropyridine calcium-channel blocker | Tricyclic antidepressant (TCA) |
| CAS | 88150-42-9 | 50-48-6 |
| ATC | C08CA01 | N06AA09 |
| Molecular weight | 408.88 g/mol | 277.40 g/mol |
| Brands with this active ingredient | 1 | 1 |
What they share
Amlodipine and Amitriptyline share the common regulatory framework for prescription active ingredients, bioequivalence standards for generics, and pharmacist oversight. Beyond that, points in common are limited.
Key differences
Amlodipine acts by a different mechanism than Amitriptyline, with indications that barely overlap. Comparing the two is useful when a clinician has mentioned both in the same context or the patient wants to understand why one was prescribed instead of the other.
Mechanisms compared
Amlodipine: Amlodipine selectively blocks L-type calcium channels in vascular smooth muscle, reducing transmembrane calcium influx and producing peripheral arterial vasodilation. Amitriptyline: Amitriptyline inhibits the reuptake of serotonin and noradrenaline at central synapses, raising synaptic levels of both neurotransmitters.
Indications compared
Amlodipine: Amlodipine is approved in adults for the treatment of essential hypertension and chronic stable angina, and for vasospastic (Prinzmetal's) angina. Amitriptyline: Amitriptyline is approved for major depressive disorder, but contemporary use is dominated by low-dose off-label indications: neuropathic pain, fibromyalgia, chronic tension headache, migraine prevention, irritable bowel…
Safety profile
Amlodipine: Common adverse effects include peripheral oedema (typically ankle), flushing, headache, palpitations and fatigue, mostly dose-related. Amitriptyline: Common adverse effects reflect anticholinergic, antihistaminic and α1-blocking activity: dry mouth, constipation, urinary hesitancy, blurred vision, sedation, weight gain and orthostatic hypotension.
Frequently asked questions
Is Amlodipine better than Amitriptyline? ▾
Amlodipine and Amitriptyline are not "better or worse" — they treat different things. The sensible question is which fits your specific need.
Can Amlodipine and Amitriptyline be combined? ▾
Whether they can be combined depends on the indications and the interaction profile of each. If both are in a single prescription, the prescriber has weighed it; in self-medication they should never be combined.
Do they have the same side-effect profile? ▾
No — they belong to different classes and have distinct side-effect profiles. Each has its own prescribing information.
Products with Amlodipine
Products with Amitriptyline
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.