Ativan vs Klonopin: side-by-side comparison
Ativan (Lorazepam) and Klonopin (Clonazepam) both belong to the Anti-anxiety Medications class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Ativan | Klonopin |
|---|---|---|
| Active ingredient | Lorazepam | Clonazepam |
| Manufacturer | Pfizer | Genentech (Roche) |
| Class | Anti-anxiety Medications | Anti-anxiety Medications |
| Strengths | 0.5mg, 1mg, 2mg | 0.5mg, 1mg, 2mg |
| Forms | tablet, oral concentrate, injection | tablet, orally disintegrating tablet |
What's the same
Ativan and Klonopin both belong to the Anti-anxiety Medications class and are used for partially overlapping indications. The active ingredients — Lorazepam vs Clonazepam — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Lorazepam vs Clonazepam), strengths (0.5mg, 1mg, 2mg vs 0.5mg, 1mg, 2mg), forms (tablet, oral concentrate, injection vs tablet, orally disintegrating tablet), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Ativan: Lorazepam binds the benzodiazepine site of the GABA-A receptor and allosterically enhances inhibitory chloride conductance. Klonopin: Clonazepam binds to the benzodiazepine site of the GABA-A receptor and allosterically enhances inhibitory chloride conductance, hyperpolarising central nervous system neurons.
When Ativan is preferred
Ativan is approved in adults for the short-term management of anxiety disorders and anxiety-related insomnia.
When Klonopin is preferred
Klonopin is approved in adults for the treatment of certain seizure types, including absence and atypical absence seizures, myoclonic and akinetic seizures, and as adjunctive therapy in Lennox-Gastaut syndrome.
Frequently asked questions
Is Ativan or Klonopin better? ▾
There is no single answer. Ativan and Klonopin both belong to the Anti-anxiety Medications class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Ativan to Klonopin? ▾
Switching within the Anti-anxiety Medications class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Ativan and Klonopin have the same side effects? ▾
They share many of the Anti-anxiety Medications class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
More Ativan comparisons
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.