Anti-Depressants with antidepressants: interactions
Many adults take an antidepressant for mood, anxiety or chronic pain. The combination with Anti-Depressants (Anti-Depressants) is common and, for most antidepressant classes, well tolerated. A few specific combinations require attention because of additive effects or shared metabolic pathways.
Antidepressant interaction landscape
SSRIs, SNRIs, TCAs, MAOIs and atypical antidepressants each interact differently. SSRIs are the most commonly co-prescribed and usually have minor or no clinically meaningful interaction with Amitriptyline, Bupropion, Citalopram, Duloxetine, Escitalopram, Fluoxetine, Mirtazapine, Paroxetine, Sertraline, Trazodone, Venlafaxine at 10mg, 20mg, 40mg, 30mg, 60mg. MAOIs require special caution with many medications. Tricyclics can amplify cardiovascular and sedative effects of some Anti-Depressants agents.
Practical guidance
According to the prescribing information for Amitriptyline, Bupropion, Citalopram, Duloxetine, Escitalopram, Fluoxetine, Mirtazapine, Paroxetine, Sertraline, Trazodone, Venlafaxine, any change in antidepressant therapy should be reviewed alongside Anti-Depressants dosing. Switching antidepressants — particularly to or from MAOIs — usually requires a washout period before resuming Anti-Depressants at the standard 10mg, 20mg, 40mg, 30mg, 60mg schedule.
Frequently asked questions
Can I take Anti-Depressants on an SSRI? ▾
For most SSRIs and most Anti-Depressants agents, the combination is acceptable with normal monitoring. A few combinations require dose adjustment or alternative selection. The prescriber confirms based on the specific antidepressant and the active ingredient Amitriptyline, Bupropion, Citalopram, Duloxetine, Escitalopram, Fluoxetine, Mirtazapine, Paroxetine, Sertraline, Trazodone, Venlafaxine.
Are there antidepressants to avoid with Anti-Depressants? ▾
MAOIs are the antidepressant class most often flagged for caution with many medications. Other interactions depend on Amitriptyline, Bupropion, Citalopram, Duloxetine, Escitalopram, Fluoxetine, Mirtazapine, Paroxetine, Sertraline, Trazodone, Venlafaxine and the specific antidepressant; a pharmacist review is the practical safeguard at 10mg, 20mg, 40mg, 30mg, 60mg.
Medications in Anti-Depressants
More on Anti-Depressants
- With alcoholAnti-Depressants and alcohol — is it safe to drink?
- With foodShould Anti-Depressants be taken with food?
- Side effectsAnti-Depressants side effects: common, rare and warning signs
- For older adultsAnti-Depressants after 60: doses and safety in older adults
- For womenAnti-Depressants for women: indications and considerations
- For menAnti-Depressants for men: indications and considerations
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.