Cymbalta vs Paxil: side-by-side comparison
Cymbalta (Duloxetine) and Paxil (Paroxetine) both belong to the Antidepressiva class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Cymbalta | Paxil |
|---|---|---|
| Active ingredient | Duloxetine | Paroxetine |
| Manufacturer | Eli Lilly | GlaxoSmithKline |
| Class | Antidepressiva | Antidepressiva |
| Strengths | 20mg, 30mg, 60mg | 10mg, 20mg, 30mg, 40mg |
| Forms | capsule | tablet |
What's the same
Cymbalta and Paxil both belong to the Antidepressiva class and are used for partially overlapping indications. The active ingredients — Duloxetine vs Paroxetine — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Duloxetine vs Paroxetine), strengths (20mg, 30mg, 60mg vs 10mg, 20mg, 30mg, 40mg), forms (capsule vs tablet), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Cymbalta: Cymbalta hemmt die Wiederaufnahme von Serotonin und Noradrenalin an der Synapse. Paxil: Paroxetin hemmt selektiv den Serotonin-Wiederaufnahmetransporter (SERT) und erhöht so die synaptische Serotoninverfügbarkeit.
When Cymbalta is preferred
Cymbalta ist zur Behandlung der Major Depression, der generalisierten Angststörung, diabetischer peripherer neuropathischer Schmerzen, Fibromyalgie und chronischer muskuloskelettaler Schmerzen zugelassen.
When Paxil is preferred
Paxil ist je nach Region zur Behandlung der Major Depression, der generalisierten Angststörung, der sozialen Angststörung, der Panikstörung, der Zwangsstörung und der posttraumatischen Belastungsstörung zugelassen.
Häufig gestellte Fragen
Is Cymbalta or Paxil better? ▾
There is no single answer. Cymbalta and Paxil both belong to the Antidepressiva class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Cymbalta to Paxil? ▾
Switching within the Antidepressiva class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Cymbalta and Paxil have the same side effects? ▾
They share many of the Antidepressiva class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
More Cymbalta comparisons
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