Cymbalta vs Effexor: side-by-side comparison
Cymbalta (Duloxetine) and Effexor (Venlafaxine) both belong to the Antidepressiva class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Cymbalta | Effexor |
|---|---|---|
| Active ingredient | Duloxetine | Venlafaxine |
| Manufacturer | Eli Lilly | Wyeth/Pfizer |
| Class | Antidepressiva | Antidepressiva |
| Strengths | 20mg, 30mg, 60mg | 37.5mg, 75mg, 150mg |
| Forms | capsule | capsule |
What's the same
Cymbalta and Effexor both belong to the Antidepressiva class and are used for partially overlapping indications. The active ingredients — Duloxetine vs Venlafaxine — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Duloxetine vs Venlafaxine), strengths (20mg, 30mg, 60mg vs 37.5mg, 75mg, 150mg), forms (capsule vs capsule), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Cymbalta: Cymbalta hemmt die Wiederaufnahme von Serotonin und Noradrenalin an der Synapse. Effexor: Effexor hemmt die Wiederaufnahme von Serotonin und Noradrenalin an der Synapse.
When Cymbalta is preferred
Cymbalta ist zur Behandlung der Major Depression, der generalisierten Angststörung, diabetischer peripherer neuropathischer Schmerzen, Fibromyalgie und chronischer muskuloskelettaler Schmerzen zugelassen.
When Effexor is preferred
Effexor XR ist zur Behandlung der Major Depression, der generalisierten Angststörung, der sozialen Phobie und der Panikstörung zugelassen.
Häufig gestellte Fragen
Is Cymbalta or Effexor better? ▾
There is no single answer. Cymbalta and Effexor both belong to the Antidepressiva class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Cymbalta to Effexor? ▾
Switching within the Antidepressiva class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Cymbalta and Effexor have the same side effects? ▾
They share many of the Antidepressiva class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
More Cymbalta comparisons
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