Restoril vs Temazepam: are they the same?
Restoril is a commercial brand whose active ingredient is exactly Temazepam. This page explains what that means in practice: where they differ (brand, manufacturer, price, available strengths), why they are clinically equivalent, and when the brand or an authorised generic is the better choice.
Are they the same?
Yes — Restoril contains Temazepam as its active ingredient. Talking about "Restoril" in clinical terms is the same as talking about Temazepam at the dose strengths 7.5mg, 15mg, 22.5mg, 30mg. The differences from the authorised generic are brand, manufacturer (Mallinckrodt), excipients, tablet appearance and price — not the active molecule itself.
When Restoril is used
レストリルは成人における不眠症の短期治療、特に睡眠維持困難が顕著な場合に承認されています。臨床ガイドラインによれば、処方は必要最短期間の最小有効量に限定すべきで、通常2-4週間とし、定期的に再評価する必要があります。レストリルは慢性不眠症の第一選択治療や小児には適応がありません。
Mechanisms compared
Because they share the same active ingredient, the mechanism is identical: テマゼパムはGABA-A受容体のベンゾジアゼピン結合部位に結合し、抑制性塩素イオン伝導をアロステリックに増強します。中枢神経系ニューロンの過分極が鎮静、睡眠導入、総睡眠時間の延長、夜間覚醒の減少をもたらします。8-20時間の中等度の半減期は夜間を通じての睡眠維持に有利であり、高用量または高齢者では翌日への持ち越し効果が生じる可能性があります。
Brand or generic — which to choose?
For most patients, authorised generics of Temazepam are clinically equivalent substitutes for Restoril and typically cost substantially less. The practical differences are manufacturer, excipients (rarely matters except in specific sensitivities), tablet appearance and price. The brand is preferred by some patients for personal reasons or insurance coverage; the generic is the default when cost matters.
よくある質問
Is Restoril the same as Temazepam? ▾
Clinically yes — Restoril is the brand and Temazepam is its active ingredient. At equivalent doses (7.5mg, 15mg, 22.5mg, 30mg) they produce the same effect. The difference is brand, manufacturer (Mallinckrodt) and price.
Is generic Temazepam as effective as Restoril? ▾
Yes. Authorised generics of Temazepam must demonstrate bioequivalence to the brand. The active substance is the same; average effect is the same. Price is usually substantially lower.
Why does Restoril cost more than generic Temazepam? ▾
The price difference reflects originator development costs, brand recognition and competition among generic manufacturers. The molecule is identical; the cost is not.
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