Caverject vs Alprostadil: are they the same?
Caverject is a commercial brand whose active ingredient is exactly Alprostadil. This page explains what that means in practice: where they differ (brand, manufacturer, price, available strengths), why they are clinically equivalent, and when the brand or an authorised generic is the better choice.
Are they the same?
Yes — Caverject contains Alprostadil as its active ingredient. Talking about "Caverject" in clinical terms is the same as talking about Alprostadil at the dose strengths 10mcg, 20mcg, 40mcg. The differences from the authorised generic are brand, manufacturer (Pfizer), excipients, tablet appearance and price — not the active molecule itself.
When Caverject is used
カベジェクトは成人男性の血管性、神経性、心因性または混合性病因の勃起不全治療に承認されています。前立腺全摘後の陰茎リハビリテーション、PDE5阻害薬が無効または使用できない患者、経口治療に対する循環器系の禁忌を有する患者で広く使用されています。現行のEDガイドラインによれば、カベジェクトは経口PDE5阻害薬に次ぐ二次治療ですが、選択された集団では一次治療となります。
Mechanisms compared
Because they share the same active ingredient, the mechanism is identical: アルプロスタジルは陰茎海綿体平滑筋のプロスタグランジンE受容体に結合し、PDE5阻害薬が利用する一酸化窒素経路とは独立してcAMP介在性の海綿体平滑筋弛緩を引き起こします。これにより海綿体で直接的な血管拡張が起こり、5~20分以内に確実な充血が得られます。本機序は性的刺激や正常なNO経路を必要としないため、経口PDE5阻害薬に反応しない多くの患者でもカベジェクトは効果を発揮します。
Brand or generic — which to choose?
For most patients, authorised generics of Alprostadil are clinically equivalent substitutes for Caverject and typically cost substantially less. The practical differences are manufacturer, excipients (rarely matters except in specific sensitivities), tablet appearance and price. The brand is preferred by some patients for personal reasons or insurance coverage; the generic is the default when cost matters.
よくある質問
Is Caverject the same as Alprostadil? ▾
Clinically yes — Caverject is the brand and Alprostadil is its active ingredient. At equivalent doses (10mcg, 20mcg, 40mcg) they produce the same effect. The difference is brand, manufacturer (Pfizer) and price.
Is generic Alprostadil as effective as Caverject? ▾
Yes. Authorised generics of Alprostadil must demonstrate bioequivalence to the brand. The active substance is the same; average effect is the same. Price is usually substantially lower.
Why does Caverject cost more than generic Alprostadil? ▾
The price difference reflects originator development costs, brand recognition and competition among generic manufacturers. The molecule is identical; the cost is not.
本ウェブサイトの情報は参考および教育目的のみで提供されます。資格を有する医療従事者への相談に代わるものではありません。