Zoloft vs Desyrel: side-by-side comparison
Zoloft (Sertraline) and Desyrel (Trazodone) both belong to the Antidépresseurs class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Zoloft | Desyrel |
|---|---|---|
| Active ingredient | Sertraline | Trazodone |
| Manufacturer | Pfizer | Various generics |
| Class | Antidépresseurs | Antidépresseurs |
| Strengths | 25mg, 50mg, 100mg | 50mg, 100mg, 150mg, 300mg |
| Forms | tablet | tablet |
What's the same
Zoloft and Desyrel both belong to the Antidépresseurs class and are used for partially overlapping indications. The active ingredients — Sertraline vs Trazodone — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Sertraline vs Trazodone), strengths (25mg, 50mg, 100mg vs 50mg, 100mg, 150mg, 300mg), forms (tablet vs tablet), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Zoloft: La sertraline agit en bloquant sélectivement le transporteur de la sérotonine, empêchant la recapture de la sérotonine depuis la fente synaptique et augmentant sa concentration synaptique. Desyrel: La trazodone est classée parmi les antagonistes des récepteurs de la sérotonine et inhibiteurs de sa recapture (SARI).
When Zoloft is preferred
Zoloft est autorisé chez l'adulte dans la dépression caractérisée, le trouble panique avec ou sans agoraphobie, le trouble obsessionnel compulsif, l'état de stress post-traumatique, l'anxiété sociale et le trouble dysphorique prémenstruel.
When Desyrel is preferred
Desyrel (trazodone) est autorisé dans la dépression caractérisée.
Questions fréquentes
Is Zoloft or Desyrel better? ▾
There is no single answer. Zoloft and Desyrel both belong to the Antidépresseurs class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Zoloft to Desyrel? ▾
Switching within the Antidépresseurs class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Zoloft and Desyrel have the same side effects? ▾
They share many of the Antidépresseurs class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
More Zoloft comparisons
Les informations publiées sur ce site sont fournies à titre documentaire et pédagogique. Elles ne remplacent pas l'avis d'un professionnel de santé qualifié.