Desyrel vs Zoloft: side-by-side comparison
Desyrel (Trazodone) and Zoloft (Sertraline) both belong to the Antidépresseurs class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Desyrel | Zoloft |
|---|---|---|
| Active ingredient | Trazodone | Sertraline |
| Manufacturer | Various generics | Pfizer |
| Class | Antidépresseurs | Antidépresseurs |
| Strengths | 50mg, 100mg, 150mg, 300mg | 25mg, 50mg, 100mg |
| Forms | tablet | tablet |
What's the same
Desyrel and Zoloft both belong to the Antidépresseurs class and are used for partially overlapping indications. The active ingredients — Trazodone vs Sertraline — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Trazodone vs Sertraline), strengths (50mg, 100mg, 150mg, 300mg vs 25mg, 50mg, 100mg), forms (tablet vs tablet), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Desyrel: La trazodone est classée parmi les antagonistes des récepteurs de la sérotonine et inhibiteurs de sa recapture (SARI). Zoloft: La sertraline agit en bloquant sélectivement le transporteur de la sérotonine, empêchant la recapture de la sérotonine depuis la fente synaptique et augmentant sa concentration synaptique.
When Desyrel is preferred
Desyrel (trazodone) est autorisé dans la dépression caractérisée.
When Zoloft is preferred
Zoloft est autorisé chez l'adulte dans la dépression caractérisée, le trouble panique avec ou sans agoraphobie, le trouble obsessionnel compulsif, l'état de stress post-traumatique, l'anxiété sociale et le trouble dysphorique prémenstruel.
Questions fréquentes
Is Desyrel or Zoloft better? ▾
There is no single answer. Desyrel and Zoloft both belong to the Antidépresseurs class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Desyrel to Zoloft? ▾
Switching within the Antidépresseurs class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Desyrel and Zoloft have the same side effects? ▾
They share many of the Antidépresseurs class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
More Desyrel comparisons
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