Serotonin-norepinephrine reuptake inhibitor (SNRI)
Venlafaxine with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Venlafaxine (Venlafaxine). Most antibiotics do not interfere meaningfully with Venlafaxine at 37.5mg, 75mg, 150mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Serotonin-norepinephrine reuptake inhibitor (SNRI) agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Venlafaxine at 37.5mg, 75mg, 150mg.
Practical guidance
According to the prescribing information for Venlafaxine, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Venlafaxine is co-administered. Adjusted 37.5mg, 75mg, 150mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Venlafaxine during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Venlafaxine is metabolised and may need a temporary 37.5mg, 75mg, 150mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Venlafaxine regimen.
Will antibiotics make Venlafaxine stop working? ▾
Most antibiotics do not affect Venlafaxine efficacy. Rifampicin and a few others can lower Venlafaxine levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Venlafaxine
More on Venlafaxine
- With alcoholVenlafaxine and alcohol — is it safe to drink?
- With foodShould Venlafaxine be taken with food?
- Side effectsVenlafaxine side effects: common, rare and warning signs
- Dosage guideVenlafaxine dosage guide: how much to take and when
- OnsetHow fast does Venlafaxine start working?
- DurationHow long does Venlafaxine last?
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