PDE5 inhibitor
Tadalafil and cannabis (marijuana, THC)
As cannabis becomes legal or decriminalised in more jurisdictions, the practical question of combining it with prescription medication comes up regularly. Tadalafil (Tadalafil) and cannabis share several pharmacological pathways, and the combination at 20mg, 2.5mg, 5mg, 10mg is not automatically benign even where both are legal.
How cannabis affects Tadalafil
THC and other cannabinoids are metabolised partly by hepatic CYP enzymes, including CYP3A4 — the same pathway used by many PDE5 inhibitor medications. Frequent cannabis use can shift the metabolism of Tadalafil mildly. THC also has cardiovascular effects (increased heart rate, blood pressure changes) and central nervous system effects that can stack with Tadalafil's side-effect profile.
Practical guidance
Occasional moderate cannabis use is unlikely to cause clinically meaningful problems for most adults on Tadalafil at 20mg, 2.5mg, 5mg, 10mg. Heavy daily use, edibles with high THC content, or cannabis combined with alcohol substantially raise the risk of dizziness, hypotension, impaired judgement and amplified side effects from Tadalafil. According to the prescribing information, the full list of recreational substances should be disclosed to the prescriber.
Frequently asked questions
Can I use cannabis while taking Tadalafil? ▾
For most adults at 20mg, 2.5mg, 5mg, 10mg, occasional moderate cannabis is tolerated, but heavy daily use is not advised because of metabolic and additive cardiovascular effects with Tadalafil. The safe practice is to mention it to the prescriber.
Does CBD interact with Tadalafil? ▾
CBD inhibits several CYP enzymes including CYP3A4, which can raise plasma levels of medications that go through that pathway. For Tadalafil specifically, this depends on whether Tadalafil uses CYP3A4. Daily high-dose CBD products warrant a pharmacist check.
Products containing Tadalafil
More on Tadalafil
- With alcoholTadalafil and alcohol — is it safe to drink?
- With foodShould Tadalafil be taken with food?
- Side effectsTadalafil side effects: common, rare and warning signs
- Dosage guideTadalafil dosage guide: how much to take and when
- OnsetHow fast does Tadalafil start working?
- DurationHow long does Tadalafil last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.