HMG-CoA reductase inhibitor (statin)
Rosuvastatin with vitamins, minerals and herbal supplements
Supplements are widely used and rarely disclosed to the prescriber, which makes them a common source of unrecognised interactions with Rosuvastatin (Rosuvastatin). Many supplements are inert or harmless, but a small number — particularly herbal extracts and high-dose vitamins — can affect how Rosuvastatin works at 5mg, 10mg, 20mg, 40mg.
High-priority supplement interactions
St John's Wort is the herbal supplement most often flagged for interactions because it strongly induces CYP3A4 and reduces plasma levels of many medications including several HMG-CoA reductase inhibitor (statin) agents. Grapefruit-extract supplements work in the opposite direction. High-dose vitamin K affects anticoagulants. Calcium and iron can chelate certain antibiotics.
Practical disclosure
According to the prescribing information for Rosuvastatin, the medication list reviewed by the pharmacist should always include supplements. Most multivitamins at standard doses do not interact meaningfully with Rosuvastatin at 5mg, 10mg, 20mg, 40mg, but anything herbal, anything single-ingredient at high dose, and anything new started recently is worth flagging.
Frequently asked questions
Are vitamins safe with Rosuvastatin? ▾
Standard-dose multivitamins are usually fine with Rosuvastatin at 5mg, 10mg, 20mg, 40mg. High-dose single vitamins (e.g. vitamin K, large doses of vitamin E) can interact with specific medication classes; the pharmacist confirms whether these matter for Rosuvastatin.
Should I tell the pharmacist about herbal supplements? ▾
Yes — particularly St John's Wort, ginseng, ginkgo, garlic extract and any concentrated herbal formulation. Several of these have meaningful interactions with prescription medications including some agents in the HMG-CoA reductase inhibitor (statin) class.
Products containing Rosuvastatin
More on Rosuvastatin
- With alcoholRosuvastatin and alcohol — is it safe to drink?
- With foodShould Rosuvastatin be taken with food?
- Side effectsRosuvastatin side effects: common, rare and warning signs
- Dosage guideRosuvastatin dosage guide: how much to take and when
- OnsetHow fast does Rosuvastatin start working?
- DurationHow long does Rosuvastatin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.