HMG-CoA reductase inhibitor (statin)
Rosuvastatin with antidepressants: interactions
Many adults take an antidepressant for mood, anxiety or chronic pain. The combination with Rosuvastatin (Rosuvastatin) is common and, for most antidepressant classes, well tolerated. A few specific combinations require attention because of additive effects or shared metabolic pathways.
Antidepressant interaction landscape
SSRIs, SNRIs, TCAs, MAOIs and atypical antidepressants each interact differently. SSRIs are the most commonly co-prescribed and usually have minor or no clinically meaningful interaction with Rosuvastatin at 5mg, 10mg, 20mg, 40mg. MAOIs require special caution with many medications. Tricyclics can amplify cardiovascular and sedative effects of some HMG-CoA reductase inhibitor (statin) agents.
Practical guidance
According to the prescribing information for Rosuvastatin, any change in antidepressant therapy should be reviewed alongside Rosuvastatin dosing. Switching antidepressants — particularly to or from MAOIs — usually requires a washout period before resuming Rosuvastatin at the standard 5mg, 10mg, 20mg, 40mg schedule.
Frequently asked questions
Can I take Rosuvastatin on an SSRI? ▾
For most SSRIs and most HMG-CoA reductase inhibitor (statin) agents, the combination is acceptable with normal monitoring. A few combinations require dose adjustment or alternative selection. The prescriber confirms based on the specific antidepressant and the active ingredient Rosuvastatin.
Are there antidepressants to avoid with Rosuvastatin? ▾
MAOIs are the antidepressant class most often flagged for caution with many medications. Other interactions depend on Rosuvastatin and the specific antidepressant; a pharmacist review is the practical safeguard at 5mg, 10mg, 20mg, 40mg.
Products containing Rosuvastatin
More on Rosuvastatin
- With alcoholRosuvastatin and alcohol — is it safe to drink?
- With foodShould Rosuvastatin be taken with food?
- Side effectsRosuvastatin side effects: common, rare and warning signs
- Dosage guideRosuvastatin dosage guide: how much to take and when
- OnsetHow fast does Rosuvastatin start working?
- DurationHow long does Rosuvastatin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.