Proton pump inhibitor
Omeprazole with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Omeprazole (Omeprazole). Most antibiotics do not interfere meaningfully with Omeprazole at 10mg, 20mg, 40mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Proton pump inhibitor agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Omeprazole at 10mg, 20mg, 40mg.
Practical guidance
According to the prescribing information for Omeprazole, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Omeprazole is co-administered. Adjusted 10mg, 20mg, 40mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Omeprazole during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Omeprazole is metabolised and may need a temporary 10mg, 20mg, 40mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Omeprazole regimen.
Will antibiotics make Omeprazole stop working? ▾
Most antibiotics do not affect Omeprazole efficacy. Rifampicin and a few others can lower Omeprazole levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Omeprazole
More on Omeprazole
- With alcoholOmeprazole and alcohol — is it safe to drink?
- With foodShould Omeprazole be taken with food?
- Side effectsOmeprazole side effects: common, rare and warning signs
- Dosage guideOmeprazole dosage guide: how much to take and when
- OnsetHow fast does Omeprazole start working?
- DurationHow long does Omeprazole last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.