Atypical antidepressant (NaSSA)
Mirtazapine dosage guide: how much to take and when
Choosing the right dose of Mirtazapine (Mirtazapine) is the most important practical decision after starting therapy. Mirtazapine is supplied as tablet in 7.5mg, 15mg, 30mg, 45mg, and the right dose for a given person depends on the indication, age, comorbidities and tolerance to the active ingredient Mirtazapine.
Starting dose and titration
According to the prescribing information, most adults begin Mirtazapine at the lowest available strength of 7.5mg, 15mg, 30mg, 45mg and titrate up only if symptom control is insufficient and tolerability is good. Higher doses are reserved for selected cases. Older adults, people with renal or hepatic impairment, and those taking interacting medications should usually start at the lowest dose.
When to adjust
Dose adjustment is guided by symptom response and side effect burden, not by arbitrary schedules. Mirtazapine antagonises presynaptic α2-adrenergic autoreceptors and heteroreceptors, increasing noradrenaline and serotonin release. If side effects are limiting at a given dose, going down a step is usually preferred over stopping abruptly. If the response is incomplete after several weeks, a higher dose can be tried under medical supervision.
Frequently asked questions
What is the standard starting dose of Mirtazapine? ▾
Most adults start Mirtazapine at the lowest strength of 7.5mg, 15mg, 30mg, 45mg, with adjustment based on symptom response and tolerance. Older adults and those with reduced kidney or liver function generally start lower. The prescriber decides the exact starting dose for each person.
Can I take a higher dose of Mirtazapine if it isn't working? ▾
Higher doses of Mirtazapine should only be used after consulting the prescriber. Doubling on your own is unsafe, especially with active ingredients in the Atypical antidepressant (NaSSA) class. The prescriber can confirm whether titration is appropriate or whether the medication needs to be changed.
Products containing Mirtazapine
More on Mirtazapine
- With alcoholMirtazapine and alcohol — is it safe to drink?
- With foodShould Mirtazapine be taken with food?
- Side effectsMirtazapine side effects: common, rare and warning signs
- OnsetHow fast does Mirtazapine start working?
- DurationHow long does Mirtazapine last?
- Missed doseWhat to do if you miss a dose of Mirtazapine
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