NSAID (preferential COX-2 inhibitor)
Meloxicam with antidepressants: interactions
Many adults take an antidepressant for mood, anxiety or chronic pain. The combination with Meloxicam (Meloxicam) is common and, for most antidepressant classes, well tolerated. A few specific combinations require attention because of additive effects or shared metabolic pathways.
Antidepressant interaction landscape
SSRIs, SNRIs, TCAs, MAOIs and atypical antidepressants each interact differently. SSRIs are the most commonly co-prescribed and usually have minor or no clinically meaningful interaction with Meloxicam at 7.5mg, 15mg. MAOIs require special caution with many medications. Tricyclics can amplify cardiovascular and sedative effects of some NSAID (preferential COX-2 inhibitor) agents.
Practical guidance
According to the prescribing information for Meloxicam, any change in antidepressant therapy should be reviewed alongside Meloxicam dosing. Switching antidepressants — particularly to or from MAOIs — usually requires a washout period before resuming Meloxicam at the standard 7.5mg, 15mg schedule.
Frequently asked questions
Can I take Meloxicam on an SSRI? ▾
For most SSRIs and most NSAID (preferential COX-2 inhibitor) agents, the combination is acceptable with normal monitoring. A few combinations require dose adjustment or alternative selection. The prescriber confirms based on the specific antidepressant and the active ingredient Meloxicam.
Are there antidepressants to avoid with Meloxicam? ▾
MAOIs are the antidepressant class most often flagged for caution with many medications. Other interactions depend on Meloxicam and the specific antidepressant; a pharmacist review is the practical safeguard at 7.5mg, 15mg.
Products containing Meloxicam
More on Meloxicam
- With alcoholMeloxicam and alcohol — is it safe to drink?
- With foodShould Meloxicam be taken with food?
- Side effectsMeloxicam side effects: common, rare and warning signs
- Dosage guideMeloxicam dosage guide: how much to take and when
- OnsetHow fast does Meloxicam start working?
- DurationHow long does Meloxicam last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.