NSAID (preferential COX-2 inhibitor)
Meloxicam with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Meloxicam (Meloxicam). Most antibiotics do not interfere meaningfully with Meloxicam at 7.5mg, 15mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some NSAID (preferential COX-2 inhibitor) agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Meloxicam at 7.5mg, 15mg.
Practical guidance
According to the prescribing information for Meloxicam, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Meloxicam is co-administered. Adjusted 7.5mg, 15mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Meloxicam during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Meloxicam is metabolised and may need a temporary 7.5mg, 15mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Meloxicam regimen.
Will antibiotics make Meloxicam stop working? ▾
Most antibiotics do not affect Meloxicam efficacy. Rifampicin and a few others can lower Meloxicam levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Meloxicam
More on Meloxicam
- With alcoholMeloxicam and alcohol — is it safe to drink?
- With foodShould Meloxicam be taken with food?
- Side effectsMeloxicam side effects: common, rare and warning signs
- Dosage guideMeloxicam dosage guide: how much to take and when
- OnsetHow fast does Meloxicam start working?
- DurationHow long does Meloxicam last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.