Progestin
Who should not take Medroxyprogesterone
A contraindication is a condition under which Medroxyprogesterone (Medroxyprogesterone) should not be taken because the risk outweighs the benefit. Medroxyprogesterone has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 2.5mg, 5mg, 10mg dosing range.
Absolute contraindications
According to the prescribing information for Medroxyprogesterone, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Medroxyprogesterone can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. MPA binds progesterone receptors and produces strong progestational effects: thickening cervical mucus, inhibiting ovulation, thinning the endometrium and reducing hot flashes.
Frequently asked questions
Can someone with heart disease take Medroxyprogesterone? ▾
Some forms of heart disease are absolute contraindications for Medroxyprogesterone, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Medroxyprogesterone use under specialist supervision. The prescribing information for Medroxyprogesterone should be reviewed.
Is Medroxyprogesterone safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Medroxyprogesterone at adjusted lower 2.5mg, 5mg, 10mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Medroxyprogesterone
More on Medroxyprogesterone
- With alcoholMedroxyprogesterone and alcohol — is it safe to drink?
- With foodShould Medroxyprogesterone be taken with food?
- Side effectsMedroxyprogesterone side effects: common, rare and warning signs
- Dosage guideMedroxyprogesterone dosage guide: how much to take and when
- OnsetHow fast does Medroxyprogesterone start working?
- DurationHow long does Medroxyprogesterone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.