Benzodiazepine
Who should not take Lorazepam
A contraindication is a condition under which Lorazepam (Lorazepam) should not be taken because the risk outweighs the benefit. Lorazepam has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 0.5mg, 1mg, 2mg dosing range.
Absolute contraindications
According to the prescribing information for Lorazepam, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Lorazepam can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Lorazepam binds the benzodiazepine site of the GABA-A receptor and allosterically enhances the action of the inhibitory neurotransmitter GABA.
Frequently asked questions
Can someone with heart disease take Lorazepam? ▾
Some forms of heart disease are absolute contraindications for Lorazepam, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Lorazepam use under specialist supervision. The prescribing information for Lorazepam should be reviewed.
Is Lorazepam safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Lorazepam at adjusted lower 0.5mg, 1mg, 2mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Lorazepam
More on Lorazepam
- With alcoholLorazepam and alcohol — is it safe to drink?
- With foodShould Lorazepam be taken with food?
- Side effectsLorazepam side effects: common, rare and warning signs
- Dosage guideLorazepam dosage guide: how much to take and when
- OnsetHow fast does Lorazepam start working?
- DurationHow long does Lorazepam last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.