Thyroid hormone replacement
Who should not take Levothyroxine
A contraindication is a condition under which Levothyroxine (Levothyroxine) should not be taken because the risk outweighs the benefit. Levothyroxine has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 25mcg, 50mcg, 75mcg, 100mcg, 150mcg dosing range.
Absolute contraindications
According to the prescribing information for Levothyroxine, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Levothyroxine can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Levothyroxine replaces deficient endogenous thyroxine, which is converted in tissues to the active hormone triiodothyronine (T3) by deiodinase enzymes.
Frequently asked questions
Can someone with heart disease take Levothyroxine? ▾
Some forms of heart disease are absolute contraindications for Levothyroxine, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Levothyroxine use under specialist supervision. The prescribing information for Levothyroxine should be reviewed.
Is Levothyroxine safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Levothyroxine at adjusted lower 25mcg, 50mcg, 75mcg, 100mcg, 150mcg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Levothyroxine
More on Levothyroxine
- With alcoholLevothyroxine and alcohol — is it safe to drink?
- With foodShould Levothyroxine be taken with food?
- Side effectsLevothyroxine side effects: common, rare and warning signs
- Dosage guideLevothyroxine dosage guide: how much to take and when
- OnsetHow fast does Levothyroxine start working?
- DurationHow long does Levothyroxine last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.