Synthetic progestin (emergency contraception)
Levonorgestrel with antidepressants: interactions
Many adults take an antidepressant for mood, anxiety or chronic pain. The combination with Levonorgestrel (Levonorgestrel) is common and, for most antidepressant classes, well tolerated. A few specific combinations require attention because of additive effects or shared metabolic pathways.
Antidepressant interaction landscape
SSRIs, SNRIs, TCAs, MAOIs and atypical antidepressants each interact differently. SSRIs are the most commonly co-prescribed and usually have minor or no clinically meaningful interaction with Levonorgestrel at 1.5mg. MAOIs require special caution with many medications. Tricyclics can amplify cardiovascular and sedative effects of some Synthetic progestin (emergency contraception) agents.
Practical guidance
According to the prescribing information for Levonorgestrel, any change in antidepressant therapy should be reviewed alongside Levonorgestrel dosing. Switching antidepressants — particularly to or from MAOIs — usually requires a washout period before resuming Levonorgestrel at the standard 1.5mg schedule.
Frequently asked questions
Can I take Levonorgestrel on an SSRI? ▾
For most SSRIs and most Synthetic progestin (emergency contraception) agents, the combination is acceptable with normal monitoring. A few combinations require dose adjustment or alternative selection. The prescriber confirms based on the specific antidepressant and the active ingredient Levonorgestrel.
Are there antidepressants to avoid with Levonorgestrel? ▾
MAOIs are the antidepressant class most often flagged for caution with many medications. Other interactions depend on Levonorgestrel and the specific antidepressant; a pharmacist review is the practical safeguard at 1.5mg.
Products containing Levonorgestrel
More on Levonorgestrel
- With alcoholLevonorgestrel and alcohol — is it safe to drink?
- With foodShould Levonorgestrel be taken with food?
- Side effectsLevonorgestrel side effects: common, rare and warning signs
- Dosage guideLevonorgestrel dosage guide: how much to take and when
- OnsetHow fast does Levonorgestrel start working?
- DurationHow long does Levonorgestrel last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.