Prostaglandin analogue
Latanoprost with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Latanoprost (Latanoprost). Most antibiotics do not interfere meaningfully with Latanoprost at 0.005%, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Prostaglandin analogue agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Latanoprost at 0.005%.
Practical guidance
According to the prescribing information for Latanoprost, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Latanoprost is co-administered. Adjusted 0.005% dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Latanoprost during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Latanoprost is metabolised and may need a temporary 0.005% adjustment. The prescribing pharmacist should review any new antibiotic against the existing Latanoprost regimen.
Will antibiotics make Latanoprost stop working? ▾
Most antibiotics do not affect Latanoprost efficacy. Rifampicin and a few others can lower Latanoprost levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Latanoprost
More on Latanoprost
- With alcoholLatanoprost and alcohol — is it safe to drink?
- With foodShould Latanoprost be taken with food?
- Side effectsLatanoprost side effects: common, rare and warning signs
- Dosage guideLatanoprost dosage guide: how much to take and when
- OnsetHow fast does Latanoprost start working?
- DurationHow long does Latanoprost last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.