H2-receptor antagonist
Famotidine with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Famotidine (Famotidine). Most antibiotics do not interfere meaningfully with Famotidine at 10mg, 20mg, 40mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some H2-receptor antagonist agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Famotidine at 10mg, 20mg, 40mg.
Practical guidance
According to the prescribing information for Famotidine, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Famotidine is co-administered. Adjusted 10mg, 20mg, 40mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Famotidine during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Famotidine is metabolised and may need a temporary 10mg, 20mg, 40mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Famotidine regimen.
Will antibiotics make Famotidine stop working? ▾
Most antibiotics do not affect Famotidine efficacy. Rifampicin and a few others can lower Famotidine levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Famotidine
More on Famotidine
- With alcoholFamotidine and alcohol — is it safe to drink?
- With foodShould Famotidine be taken with food?
- Side effectsFamotidine side effects: common, rare and warning signs
- Dosage guideFamotidine dosage guide: how much to take and when
- OnsetHow fast does Famotidine start working?
- DurationHow long does Famotidine last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.