NSAID (phenylacetic acid)
Who should not take Diclofenac
A contraindication is a condition under which Diclofenac (Diclofenac) should not be taken because the risk outweighs the benefit. Diclofenac has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 25mg, 50mg, 75mg, 100mg dosing range.
Absolute contraindications
According to the prescribing information for Diclofenac, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Diclofenac can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Diclofenac reversibly inhibits cyclooxygenase enzymes COX-1 and COX-2, with somewhat greater selectivity for COX-2 than ibuprofen and naproxen.
Frequently asked questions
Can someone with heart disease take Diclofenac? ▾
Some forms of heart disease are absolute contraindications for Diclofenac, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Diclofenac use under specialist supervision. The prescribing information for Diclofenac should be reviewed.
Is Diclofenac safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Diclofenac at adjusted lower 25mg, 50mg, 75mg, 100mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Diclofenac
More on Diclofenac
- With alcoholDiclofenac and alcohol — is it safe to drink?
- With foodShould Diclofenac be taken with food?
- Side effectsDiclofenac side effects: common, rare and warning signs
- Dosage guideDiclofenac dosage guide: how much to take and when
- OnsetHow fast does Diclofenac start working?
- DurationHow long does Diclofenac last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.