P2Y12 receptor antagonist (antiplatelet)
Clopidogrel with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Clopidogrel (Clopidogrel). The combination is generally fine at 75mg, 300mg, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Clopidogrel can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Clopidogrel acts on CYP3A4 determines whether Clopidogrel affects contraception. Most agents in P2Y12 receptor antagonist (antiplatelet) have no clinically meaningful effect on the pill at 75mg, 300mg.
Practical guidance
According to the prescribing information for Clopidogrel, women on hormonal contraception should review Clopidogrel with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Clopidogrel therapy is the standard mitigation.
Frequently asked questions
Will Clopidogrel make my pill less effective? ▾
Most P2Y12 receptor antagonist (antiplatelet) medications at 75mg, 300mg do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Clopidogrel states whether the interaction is meaningful.
Do I need a backup contraceptive on Clopidogrel? ▾
Backup contraception is needed only when there is a documented interaction between Clopidogrel and the contraceptive method. For most users at 75mg, 300mg, no backup is required. The pharmacist confirms whether Clopidogrel interacts with hormonal contraception.
Products containing Clopidogrel
More on Clopidogrel
- With alcoholClopidogrel and alcohol — is it safe to drink?
- With foodShould Clopidogrel be taken with food?
- Side effectsClopidogrel side effects: common, rare and warning signs
- Dosage guideClopidogrel dosage guide: how much to take and when
- OnsetHow fast does Clopidogrel start working?
- DurationHow long does Clopidogrel last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.