Benzodiazepine
Clonazepam with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Clonazepam (Clonazepam). The combination is generally fine at 0.5mg, 1mg, 2mg, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Clonazepam can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Clonazepam acts on CYP3A4 determines whether Clonazepam affects contraception. Most agents in Benzodiazepine have no clinically meaningful effect on the pill at 0.5mg, 1mg, 2mg.
Practical guidance
According to the prescribing information for Clonazepam, women on hormonal contraception should review Clonazepam with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Clonazepam therapy is the standard mitigation.
Frequently asked questions
Will Clonazepam make my pill less effective? ▾
Most Benzodiazepine medications at 0.5mg, 1mg, 2mg do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Clonazepam states whether the interaction is meaningful.
Do I need a backup contraceptive on Clonazepam? ▾
Backup contraception is needed only when there is a documented interaction between Clonazepam and the contraceptive method. For most users at 0.5mg, 1mg, 2mg, no backup is required. The pharmacist confirms whether Clonazepam interacts with hormonal contraception.
Products containing Clonazepam
More on Clonazepam
- With alcoholClonazepam and alcohol — is it safe to drink?
- With foodShould Clonazepam be taken with food?
- Side effectsClonazepam side effects: common, rare and warning signs
- Dosage guideClonazepam dosage guide: how much to take and when
- OnsetHow fast does Clonazepam start working?
- DurationHow long does Clonazepam last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.