Selective serotonin reuptake inhibitor (SSRI)
Citalopram and cannabis (marijuana, THC)
As cannabis becomes legal or decriminalised in more jurisdictions, the practical question of combining it with prescription medication comes up regularly. Citalopram (Citalopram) and cannabis share several pharmacological pathways, and the combination at 10mg, 20mg, 40mg is not automatically benign even where both are legal.
How cannabis affects Citalopram
THC and other cannabinoids are metabolised partly by hepatic CYP enzymes, including CYP3A4 — the same pathway used by many Selective serotonin reuptake inhibitor (SSRI) medications. Frequent cannabis use can shift the metabolism of Citalopram mildly. THC also has cardiovascular effects (increased heart rate, blood pressure changes) and central nervous system effects that can stack with Citalopram's side-effect profile.
Practical guidance
Occasional moderate cannabis use is unlikely to cause clinically meaningful problems for most adults on Citalopram at 10mg, 20mg, 40mg. Heavy daily use, edibles with high THC content, or cannabis combined with alcohol substantially raise the risk of dizziness, hypotension, impaired judgement and amplified side effects from Citalopram. According to the prescribing information, the full list of recreational substances should be disclosed to the prescriber.
Frequently asked questions
Can I use cannabis while taking Citalopram? ▾
For most adults at 10mg, 20mg, 40mg, occasional moderate cannabis is tolerated, but heavy daily use is not advised because of metabolic and additive cardiovascular effects with Citalopram. The safe practice is to mention it to the prescriber.
Does CBD interact with Citalopram? ▾
CBD inhibits several CYP enzymes including CYP3A4, which can raise plasma levels of medications that go through that pathway. For Citalopram specifically, this depends on whether Citalopram uses CYP3A4. Daily high-dose CBD products warrant a pharmacist check.
Products containing Citalopram
More on Citalopram
- With alcoholCitalopram and alcohol — is it safe to drink?
- With foodShould Citalopram be taken with food?
- Side effectsCitalopram side effects: common, rare and warning signs
- Dosage guideCitalopram dosage guide: how much to take and when
- OnsetHow fast does Citalopram start working?
- DurationHow long does Citalopram last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.