Norepinephrine-dopamine reuptake inhibitor (NDRI) antidepressant
Bupropion with antidepressants: interactions
Many adults take an antidepressant for mood, anxiety or chronic pain. The combination with Bupropion (Bupropion) is common and, for most antidepressant classes, well tolerated. A few specific combinations require attention because of additive effects or shared metabolic pathways.
Antidepressant interaction landscape
SSRIs, SNRIs, TCAs, MAOIs and atypical antidepressants each interact differently. SSRIs are the most commonly co-prescribed and usually have minor or no clinically meaningful interaction with Bupropion at 75mg, 100mg, 150mg, 300mg. MAOIs require special caution with many medications. Tricyclics can amplify cardiovascular and sedative effects of some Norepinephrine-dopamine reuptake inhibitor (NDRI) antidepressant agents.
Practical guidance
According to the prescribing information for Bupropion, any change in antidepressant therapy should be reviewed alongside Bupropion dosing. Switching antidepressants — particularly to or from MAOIs — usually requires a washout period before resuming Bupropion at the standard 75mg, 100mg, 150mg, 300mg schedule.
Frequently asked questions
Can I take Bupropion on an SSRI? ▾
For most SSRIs and most Norepinephrine-dopamine reuptake inhibitor (NDRI) antidepressant agents, the combination is acceptable with normal monitoring. A few combinations require dose adjustment or alternative selection. The prescriber confirms based on the specific antidepressant and the active ingredient Bupropion.
Are there antidepressants to avoid with Bupropion? ▾
MAOIs are the antidepressant class most often flagged for caution with many medications. Other interactions depend on Bupropion and the specific antidepressant; a pharmacist review is the practical safeguard at 75mg, 100mg, 150mg, 300mg.
Products containing Bupropion
More on Bupropion
- With alcoholBupropion and alcohol — is it safe to drink?
- With foodShould Bupropion be taken with food?
- Side effectsBupropion side effects: common, rare and warning signs
- Dosage guideBupropion dosage guide: how much to take and when
- OnsetHow fast does Bupropion start working?
- DurationHow long does Bupropion last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.