Norepinephrine-dopamine reuptake inhibitor (NDRI) antidepressant
Bupropion side effects: common, rare and warning signs
Like any active medication, Bupropion (Bupropion) can produce side effects. Most are mild and transient at the standard 75mg, 100mg, 150mg, 300mg dose, but a small subset are serious and call for stopping the medication and seeking medical help. This page summarises what is typical, what is rare, and what should never be ignored.
Common side effects of Bupropion
According to the prescribing information for Bupropion, the most frequent side effects are usually dose-related and resolve on their own within hours of dosing. They typically reflect the medication's mechanism: Bupropion inhibits the reuptake of norepinephrine and dopamine, with much weaker effect on serotonin reuptake. For most users on Bupropion at 75mg, 100mg, 150mg, 300mg, side effects fade as the body adjusts, often within the first few weeks of regular use.
Serious or warning signs
Rare but serious adverse effects deserve immediate medical attention. These include severe allergic reactions, sudden vision or hearing changes, chest pain, prolonged or painful effects on cardiovascular tissue, severe abdominal pain or signs of bleeding. Anyone experiencing these on Bupropion should stop the medication and contact emergency services or a healthcare provider promptly.
Frequently asked questions
Are Bupropion side effects dangerous? ▾
For most people on a routine 75mg, 100mg, 150mg, 300mg dose, side effects are mild and short-lived. Serious adverse events are rare but real; severe allergic reactions, chest pain, sudden visual changes or other unusual symptoms are signals to stop and seek medical help.
Do Bupropion side effects go away? ▾
Most common side effects of Bupropion resolve on their own within hours of each dose or fade over the first weeks of regular use as the body adjusts. Persistent or worsening side effects should be reviewed with the prescriber, who can adjust the dose or switch the medication.
Products containing Bupropion
More on Bupropion
- With alcoholBupropion and alcohol — is it safe to drink?
- With foodShould Bupropion be taken with food?
- Dosage guideBupropion dosage guide: how much to take and when
- OnsetHow fast does Bupropion start working?
- DurationHow long does Bupropion last?
- Missed doseWhat to do if you miss a dose of Bupropion
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.