Phosphodiesterase type 5 (PDE5) inhibitor
Avanafil with statins (atorvastatin, rosuvastatin, simvastatin)
Statins are among the most widely prescribed chronic medications, often used alongside many other agents including Avanafil (Avanafil). The combination at 50mg, 100mg, 200mg is generally safe, but a small number of statin-specific interactions matter — particularly for simvastatin, which shares CYP3A4 metabolism with several common medications.
How Avanafil interacts with statins
Statins differ in their metabolic pathways: simvastatin and atorvastatin go through CYP3A4 most heavily; rosuvastatin and pravastatin take other routes and have fewer drug interactions. If Avanafil acts on CYP3A4, the combination with simvastatin or atorvastatin can raise statin levels and increase muscle-related side effects. Avanafil selectively inhibits phosphodiesterase type 5 (PDE5) in the corpus cavernosum, increasing cGMP and enhancing nitric-oxide-mediated vasodilation in response to sexual stimulation.
Practical guidance
According to the prescribing information for Avanafil, anyone on a statin should mention it before starting Avanafil at 50mg, 100mg, 200mg. The prescriber may switch the statin (e.g. from simvastatin to rosuvastatin) or adjust the statin dose during Avanafil use. Persistent muscle pain, weakness or dark urine on the combination warrants prompt evaluation.
Frequently asked questions
Can I take Avanafil with my statin? ▾
For most users at 50mg, 100mg, 200mg, yes — particularly with rosuvastatin or pravastatin which have minimal interactions with Avanafil. Simvastatin and atorvastatin combinations may need a dose review by the prescriber to avoid amplified statin effects.
Will Avanafil cause muscle pain with my statin? ▾
Muscle pain is the most common statin side effect and can be amplified when combined with medications that raise statin plasma levels. Persistent or new muscle pain on Avanafil at 50mg, 100mg, 200mg should be reported promptly so the prescriber can review the combination.
Products containing Avanafil
More on Avanafil
- With alcoholAvanafil and alcohol — is it safe to drink?
- With foodShould Avanafil be taken with food?
- Side effectsAvanafil side effects: common, rare and warning signs
- Dosage guideAvanafil dosage guide: how much to take and when
- OnsetHow fast does Avanafil start working?
- DurationHow long does Avanafil last?
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