Phosphodiesterase type 5 (PDE5) inhibitor
Who should not take Avanafil
A contraindication is a condition under which Avanafil (Avanafil) should not be taken because the risk outweighs the benefit. Avanafil has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 50mg, 100mg, 200mg dosing range.
Absolute contraindications
According to the prescribing information for Avanafil, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Avanafil can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Avanafil selectively inhibits phosphodiesterase type 5 (PDE5) in the corpus cavernosum, increasing cGMP and enhancing nitric-oxide-mediated vasodilation in response to sexual stimulation.
Frequently asked questions
Can someone with heart disease take Avanafil? ▾
Some forms of heart disease are absolute contraindications for Avanafil, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Avanafil use under specialist supervision. The prescribing information for Avanafil should be reviewed.
Is Avanafil safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Avanafil at adjusted lower 50mg, 100mg, 200mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Avanafil
More on Avanafil
- With alcoholAvanafil and alcohol — is it safe to drink?
- With foodShould Avanafil be taken with food?
- Side effectsAvanafil side effects: common, rare and warning signs
- Dosage guideAvanafil dosage guide: how much to take and when
- OnsetHow fast does Avanafil start working?
- DurationHow long does Avanafil last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.