Aminopenicillin antibiotic
Who should not take Amoxicillin
A contraindication is a condition under which Amoxicillin (Amoxicillin) should not be taken because the risk outweighs the benefit. Amoxicillin has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 250mg, 500mg, 875mg, 500/125mg, 875/125mg, 1000/62.5mg dosing range.
Absolute contraindications
According to the prescribing information for Amoxicillin, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Amoxicillin can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, which prevents the cross-linking of peptidoglycan layers and triggers bacterial autolysis.
Frequently asked questions
Can someone with heart disease take Amoxicillin? ▾
Some forms of heart disease are absolute contraindications for Amoxicillin, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Amoxicillin use under specialist supervision. The prescribing information for Amoxicillin should be reviewed.
Is Amoxicillin safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Amoxicillin at adjusted lower 250mg, 500mg, 875mg, 500/125mg, 875/125mg, 1000/62.5mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Amoxicillin
More on Amoxicillin
- With alcoholAmoxicillin and alcohol — is it safe to drink?
- With foodShould Amoxicillin be taken with food?
- Side effectsAmoxicillin side effects: common, rare and warning signs
- Dosage guideAmoxicillin dosage guide: how much to take and when
- OnsetHow fast does Amoxicillin start working?
- DurationHow long does Amoxicillin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.