What to do if Desyrel is in shortage — for the United Kingdom
Drug shortages happen periodically — manufacturing issues, supply chain disruptions, regulatory holds — and Desyrel (Trazodone) may become temporarily unavailable in some pharmacies or countries. For chronic users at 50mg, 100mg, 150mg, 300mg, knowing how to handle a shortage prevents unnecessary treatment interruption.
the United Kingdom context
Drug shortages in the United Kingdom are tracked by MHRA (Medicines and Healthcare products Regulatory Agency) when significant. For Desyrel, shortage of one strength or one manufacturer rarely means total unavailability of Trazodone — authorised generics or alternative manufacturers usually fill the gap, with the pharmacist coordinating substitution and the prescriber confirming any formulation change at 50mg, 100mg, 150mg, 300mg.
- Regulator
- MHRA (Medicines and Healthcare products Regulatory Agency)
- Currency
- GBP
How shortages work for Desyrel
When Desyrel is in shortage, the pharmacist usually has several options: dispense an authorised generic of Trazodone, source from a different manufacturer of the same active ingredient, suggest a different formulation (e.g. liquid, dispersible) or, in extended shortages, ask the prescriber to consider an alternative Anti-Depressants agent. Trazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI).
Practical steps
According to general pharmacy practice, the first step in a Desyrel shortage is to ask the pharmacist about authorised generic availability — most shortages affect a single brand or strength, not the entire supply of Trazodone at 50mg, 100mg, 150mg, 300mg. The prescriber should be informed if the pharmacist needs to substitute or change formulation. Stockpiling or buying extra outside regulated channels is not the right response.
Frequently asked questions
What do I do if my pharmacy doesn't have Desyrel? ▾
Ask the pharmacist whether an authorised generic of Trazodone is available — usually yes — or whether another pharmacy in the area has stock of Desyrel at 50mg, 100mg, 150mg, 300mg. The pharmacist can also contact the prescriber if a formulation switch is needed.
Will Desyrel come back in stock? ▾
Most shortages are resolved within weeks to months as manufacturing or supply issues are fixed. Until then, the authorised generic of Trazodone is the standard alternative and is clinically equivalent to Desyrel at the same 50mg, 100mg, 150mg, 300mg strength.
What to do if Desyrel is in shortage in other countries
- the United StatesFDA (Food and Drug Administration)
- SpainAEMPS (Agencia Española de Medicamentos y Productos Sanitarios)
- MexicoCOFEPRIS (Comisión Federal para la Protección contra Riesgos Sanitarios)
- ArgentinaANMAT (Administración Nacional de Medicamentos, Alimentos y Tecnología Médica)
- GermanyBfArM (Bundesinstitut für Arzneimittel und Medizinprodukte)
- FranceANSM (Agence nationale de sécurité du médicament et des produits de santé)
- ItalyAIFA (Agenzia Italiana del Farmaco)
- BrazilANVISA (Agência Nacional de Vigilância Sanitária)
- CanadaHealth Canada
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.