Xalatan with antibiotics: interactions and safety

Antibiotic courses are common, short-term and often combined with chronic medications such as Xalatan (Latanoprost). Most antibiotics do not interfere meaningfully with Latanoprost at 0.005%, but a few classes do, and a small number of combinations are best avoided.

Common antibiotic interactions

Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Eye Care and Ophthalmic Treatments agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Latanoprost at 0.005%.

Practical guidance

According to the prescribing information for Latanoprost, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Xalatan is co-administered. Adjusted 0.005% dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.

Frequently asked questions

Can I take Xalatan during an antibiotic course? ▾

For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Latanoprost is metabolised and may need a temporary 0.005% adjustment. The prescribing pharmacist should review any new antibiotic against the existing Xalatan regimen.

Will antibiotics make Xalatan stop working? ▾

Most antibiotics do not affect Xalatan efficacy. Rifampicin and a few others can lower Latanoprost levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.

More on Xalatan

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