Wellbutrin with antidepressants: interactions
Many adults take an antidepressant for mood, anxiety or chronic pain. The combination with Wellbutrin (Bupropion) is common and, for most antidepressant classes, well tolerated. A few specific combinations require attention because of additive effects or shared metabolic pathways.
Antidepressant interaction landscape
SSRIs, SNRIs, TCAs, MAOIs and atypical antidepressants each interact differently. SSRIs are the most commonly co-prescribed and usually have minor or no clinically meaningful interaction with Bupropion at 75mg, 100mg, 150mg, 300mg. MAOIs require special caution with many medications. Tricyclics can amplify cardiovascular and sedative effects of some Anti-Depressants agents.
Practical guidance
According to the prescribing information for Bupropion, any change in antidepressant therapy should be reviewed alongside Wellbutrin dosing. Switching antidepressants — particularly to or from MAOIs — usually requires a washout period before resuming Wellbutrin at the standard 75mg, 100mg, 150mg, 300mg schedule.
Frequently asked questions
Can I take Wellbutrin on an SSRI? ▾
For most SSRIs and most Anti-Depressants agents, the combination is acceptable with normal monitoring. A few combinations require dose adjustment or alternative selection. The prescriber confirms based on the specific antidepressant and the active ingredient Bupropion.
Are there antidepressants to avoid with Wellbutrin? ▾
MAOIs are the antidepressant class most often flagged for caution with many medications. Other interactions depend on Bupropion and the specific antidepressant; a pharmacist review is the practical safeguard at 75mg, 100mg, 150mg, 300mg.
More on Wellbutrin
- With alcoholWellbutrin and alcohol — is it safe to drink?
- With foodShould Wellbutrin be taken with food?
- Side effectsWellbutrin side effects: common, rare and warning signs
- Dosage guideWellbutrin dosage guide: how much to take and when
- OnsetHow fast does Wellbutrin start working?
- DurationHow long does Wellbutrin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.