Wellbutrin dosage guide: how much to take and when
Choosing the right dose of Wellbutrin (Bupropion) is the most important practical decision after starting therapy. Wellbutrin is supplied as tablet in 75mg, 100mg, 150mg, 300mg, and the right dose for a given person depends on the indication, age, comorbidities and tolerance to the active ingredient Bupropion.
Starting dose and titration
According to the prescribing information, most adults begin Wellbutrin at the lowest available strength of 75mg, 100mg, 150mg, 300mg and titrate up only if symptom control is insufficient and tolerability is good. Higher doses are reserved for selected cases. Older adults, people with renal or hepatic impairment, and those taking interacting medications should usually start at the lowest dose.
When to adjust
Dose adjustment is guided by symptom response and side effect burden, not by arbitrary schedules. Wellbutrin inhibits the reuptake of norepinephrine and dopamine, with much weaker effect on serotonin. If side effects are limiting at a given dose, going down a step is usually preferred over stopping abruptly. If the response is incomplete after several weeks, a higher dose can be tried under medical supervision.
Frequently asked questions
What is the standard starting dose of Wellbutrin? ▾
Most adults start Wellbutrin at the lowest strength of 75mg, 100mg, 150mg, 300mg, with adjustment based on symptom response and tolerance. Older adults and those with reduced kidney or liver function generally start lower. The prescriber decides the exact starting dose for each person.
Can I take a higher dose of Wellbutrin if it isn't working? ▾
Higher doses of Wellbutrin should only be used after consulting the prescriber. Doubling on your own is unsafe, especially with active ingredients in the Anti-Depressants class. The prescriber can confirm whether titration is appropriate or whether the medication needs to be changed.
More on Wellbutrin
- With alcoholWellbutrin and alcohol — is it safe to drink?
- With foodShould Wellbutrin be taken with food?
- Side effectsWellbutrin side effects: common, rare and warning signs
- OnsetHow fast does Wellbutrin start working?
- DurationHow long does Wellbutrin last?
- Missed doseWhat to do if you miss a dose of Wellbutrin
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.