Wellbutrin and changes in taste or smell
Changes in taste (dysgeusia) or smell (parosmia, anosmia) are an under-recognised side effect category. Some medications produce a metallic taste, a dulling of flavours, or unusual smell perception. Whether Wellbutrin (Bupropion) at 75mg, 100mg, 150mg, 300mg causes these changes depends on Bupropion; the experience is usually benign but can affect appetite and quality of life.
Why taste and smell change on Wellbutrin
Taste and smell perception relies on receptors in the tongue and nose that are sensitive to systemic medications. Bupropion can affect taste through several mechanisms: alteration of saliva composition, direct receptor interference, secretion in saliva of medication metabolites, or changes in zinc handling. Wellbutrin inhibits the reuptake of norepinephrine and dopamine, with much weaker effect on serotonin.
When changes need attention
Mild metallic taste or dulled flavours in the first weeks of Wellbutrin at 75mg, 100mg, 150mg, 300mg are common and often resolve as the body adjusts. Persistent severe loss of taste or smell, sudden onset, or interference with eating warrants prescriber review — both because the medication may need adjustment and because other causes (zinc deficiency, sinus disease) should be excluded.
Frequently asked questions
Can Wellbutrin change my taste or smell? ▾
Yes, some users report taste or smell changes on Wellbutrin at 75mg, 100mg, 150mg, 300mg — typically a metallic or dulled-flavour sensation that develops in the first weeks. The prescribing information for Bupropion lists frequency in clinical trials. Most cases are mild and resolve.
Will my taste come back when I stop Wellbutrin? ▾
For most users, taste changes attributable to Wellbutrin resolve within weeks of stopping the medication. Persistent loss after stopping, or severe loss while on therapy, deserves a clinical evaluation since other causes may be involved.
More on Wellbutrin
- With alcoholWellbutrin and alcohol — is it safe to drink?
- With foodShould Wellbutrin be taken with food?
- Side effectsWellbutrin side effects: common, rare and warning signs
- Dosage guideWellbutrin dosage guide: how much to take and when
- OnsetHow fast does Wellbutrin start working?
- DurationHow long does Wellbutrin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.