Wellbutrin and excessive sweating (or reduced sweating)
Changes in sweating — both excessive (hyperhidrosis) and reduced (hypohidrosis) — are common but underreported side effects of many medications. Wellbutrin (Bupropion) at 75mg, 100mg, 150mg, 300mg may shift sweating depending on how Bupropion affects autonomic and thermoregulatory pathways.
Why Wellbutrin can change sweating
Sweating is regulated by the sympathetic nervous system, primarily through cholinergic signalling at sweat glands. Bupropion can affect this directly (cholinergic agonism or blockade) or indirectly through changes in body temperature setpoint, vasodilation or anxiety. Wellbutrin inhibits the reuptake of norepinephrine and dopamine, with much weaker effect on serotonin. Some medications increase night sweats specifically; others reduce sweating and increase heat-intolerance risk.
Practical guidance
Excessive sweating on Wellbutrin at 75mg, 100mg, 150mg, 300mg is rarely dangerous but can affect quality of life. Mild cases are managed with antiperspirants, lighter clothing and trigger avoidance. Reduced sweating is more concerning in hot weather because it impairs cooling — care with hot environments, hydration and avoiding strenuous heat exposure is the practical response. Persistent or severe cases warrant prescriber review.
Frequently asked questions
Can Wellbutrin cause excessive sweating? ▾
For some users, yes — sweating changes on Wellbutrin at 75mg, 100mg, 150mg, 300mg are listed in the prescribing information for Bupropion when documented. Night sweats and exercise-related sweating are common patterns; persistent severe sweating warrants review.
Will reduced sweating on Wellbutrin cause overheating? ▾
Reduced sweating impairs the body's natural cooling and can raise the risk of heat exhaustion in hot weather or strenuous exercise. People on medications that reduce sweating should be cautious with heat exposure, hydrate well and consider activity timing.
More on Wellbutrin
- With alcoholWellbutrin and alcohol — is it safe to drink?
- With foodShould Wellbutrin be taken with food?
- Side effectsWellbutrin side effects: common, rare and warning signs
- Dosage guideWellbutrin dosage guide: how much to take and when
- OnsetHow fast does Wellbutrin start working?
- DurationHow long does Wellbutrin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.