Wellbutrin and surgery: what to do before and after
Surgery raises specific medication-management questions, and getting the answer right matters because both unintended drug interactions during anaesthesia and abrupt discontinuation of important chronic therapies carry risk. Whether Wellbutrin (Bupropion) needs to be stopped before surgery, continued through, or paused for a defined window depends on Bupropion and the type of procedure.
Before-surgery decision
For most chronic medications including many Anti-Depressants agents, the surgical team or anaesthetist makes the stop-or-continue decision during pre-op assessment. Considerations include bleeding risk, anaesthesia interactions, the urgency of the underlying condition and the type of procedure. According to most guidelines, surprises are avoided by listing all medications including Wellbutrin at 75mg, 100mg, 150mg, 300mg on the pre-op form.
After surgery
Post-operative resumption of Wellbutrin depends on the surgical course, the medication's impact on recovery (e.g. wound healing, gastric tolerance, mobility) and any new prescriptions added after surgery. Wellbutrin inhibits the reuptake of norepinephrine and dopamine, with much weaker effect on serotonin. Resuming on schedule is usually the goal as soon as oral intake and clinical stability allow.
Frequently asked questions
Do I need to stop Wellbutrin before surgery? ▾
It depends on Bupropion and the procedure. The pre-op assessment is where this is decided, ideally a week or more before surgery. Bring the full medication list including Wellbutrin at 75mg, 100mg, 150mg, 300mg so the team can advise.
When can I restart Wellbutrin after surgery? ▾
Resumption timing depends on the procedure, the recovery course and any interactions with new postoperative medications. Many patients restart Wellbutrin on the day of discharge or earlier; some need a longer pause. The surgical team or prescriber confirms the timing.
More on Wellbutrin
- With alcoholWellbutrin and alcohol — is it safe to drink?
- With foodShould Wellbutrin be taken with food?
- Side effectsWellbutrin side effects: common, rare and warning signs
- Dosage guideWellbutrin dosage guide: how much to take and when
- OnsetHow fast does Wellbutrin start working?
- DurationHow long does Wellbutrin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.