How to stop taking Wellbutrin
Discontinuing Wellbutrin (Bupropion) is, for most people, safe and uneventful. For a few medications and indications, abrupt stopping can cause rebound symptoms, withdrawal-like effects or loss of disease control, so a tapered stop is preferred. Whether Wellbutrin at 75mg, 100mg, 150mg, 300mg needs a taper depends on the active ingredient and the duration of use.
When to taper Wellbutrin
Tapering is generally preferred when Wellbutrin has been used continuously for months and the active ingredient Bupropion produces neuroadaptive changes that take time to reverse. Wellbutrin inhibits the reuptake of norepinephrine and dopamine, with much weaker effect on serotonin. For event-driven use, no taper is needed — simply stopping is appropriate. The prescriber decides the schedule based on the indication and dose.
What to expect when stopping
After stopping Wellbutrin at 75mg, 100mg, 150mg, 300mg, the underlying condition may return as the medication washes out — this is loss of treatment effect, not withdrawal in the strict sense. Some active ingredients also produce specific discontinuation syndromes, which a tapered stop minimises. Persistent or severe symptoms after stopping deserve medical review.
Frequently asked questions
Can I just stop taking Wellbutrin? ▾
For event-driven use of Wellbutrin at 75mg, 100mg, 150mg, 300mg, yes — simply stopping is fine. For chronic continuous use, abrupt stopping can be appropriate for some active ingredients and inadvisable for others. Confirm with the prescriber before stopping.
Will I have withdrawal from Wellbutrin? ▾
True withdrawal is uncommon with most Anti-Depressants agents. What is sometimes mistaken for withdrawal is the return of the underlying condition. The prescribing information for Bupropion lists any documented discontinuation effects to expect.
More on Wellbutrin
- With alcoholWellbutrin and alcohol — is it safe to drink?
- With foodShould Wellbutrin be taken with food?
- Side effectsWellbutrin side effects: common, rare and warning signs
- Dosage guideWellbutrin dosage guide: how much to take and when
- OnsetHow fast does Wellbutrin start working?
- DurationHow long does Wellbutrin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.