Who should not take Wegovy
A contraindication is a condition under which Wegovy (Semaglutide) should not be taken because the risk outweighs the benefit. Wegovy has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 0.25mg, 0.5mg, 1mg, 1.7mg, 2.4mg dosing range.
Absolute contraindications
According to the prescribing information for Semaglutide, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Wegovy can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Wegovy acts on the GLP-1 receptor in the central nervous system and gastrointestinal tract to reduce appetite, slow gastric emptying and increase satiety.
Frequently asked questions
Can someone with heart disease take Wegovy? ▾
Some forms of heart disease are absolute contraindications for Wegovy, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Wegovy use under specialist supervision. The prescribing information for Semaglutide should be reviewed.
Is Wegovy safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Wegovy at adjusted lower 0.25mg, 0.5mg, 1mg, 1.7mg, 2.4mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Wegovy
- With alcoholWegovy and alcohol — is it safe to drink?
- With foodShould Wegovy be taken with food?
- Side effectsWegovy side effects: common, rare and warning signs
- Dosage guideWegovy dosage guide: how much to take and when
- OnsetHow fast does Wegovy start working?
- DurationHow long does Wegovy last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.