Topamax 25mg

Forms and dosages

Topamax is administered orally twice daily with immediate-release tablets, or once daily with extended-release capsules. According to the prescribing information, doses are titrated slowly over weeks. Typical adult doses are 100-400mg per day for epilepsy and 100mg per day for migraine prevention, with target doses individualised. Substantial dose reduction is required in significant renal impairment.

Indications

Topamax is approved in adults and children aged 2 years and older for the treatment of partial-onset seizures, primary generalised tonic-clonic seizures and seizures associated with Lennox-Gastaut syndrome (as adjunctive or monotherapy depending on the country and indication). It is also approved for migraine prophylaxis in adults. According to international guidelines, Topamax is one of the recommended first-line agents for migraine prevention.