Symbicort with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Symbicort (Budesonide / Formoterol). The combination is generally fine at 80/4.5 mcg, 160/4.5 mcg, 200/6 mcg, 400/12 mcg, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Symbicort can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Budesonide, Formoterol acts on CYP3A4 determines whether Symbicort affects contraception. Most agents in Respiratory Medications have no clinically meaningful effect on the pill at 80/4.5 mcg, 160/4.5 mcg, 200/6 mcg, 400/12 mcg.
Practical guidance
According to the prescribing information for Budesonide, Formoterol, women on hormonal contraception should review Symbicort with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Symbicort therapy is the standard mitigation.
Frequently asked questions
Will Symbicort make my pill less effective? ▾
Most Respiratory Medications medications at 80/4.5 mcg, 160/4.5 mcg, 200/6 mcg, 400/12 mcg do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Budesonide, Formoterol states whether the interaction is meaningful.
Do I need a backup contraceptive on Symbicort? ▾
Backup contraception is needed only when there is a documented interaction between Symbicort and the contraceptive method. For most users at 80/4.5 mcg, 160/4.5 mcg, 200/6 mcg, 400/12 mcg, no backup is required. The pharmacist confirms whether Budesonide, Formoterol interacts with hormonal contraception.
More on Symbicort
- With alcoholSymbicort and alcohol — is it safe to drink?
- With foodShould Symbicort be taken with food?
- Side effectsSymbicort side effects: common, rare and warning signs
- Dosage guideSymbicort dosage guide: how much to take and when
- OnsetHow fast does Symbicort start working?
- DurationHow long does Symbicort last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.