Saxenda with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Saxenda (Liraglutide). The combination is generally fine at 6 mg/mL, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Saxenda can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Liraglutide acts on CYP3A4 determines whether Saxenda affects contraception. Most agents in Diabetes Treatment have no clinically meaningful effect on the pill at 6 mg/mL.
Practical guidance
According to the prescribing information for Liraglutide, women on hormonal contraception should review Saxenda with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Saxenda therapy is the standard mitigation.
Frequently asked questions
Will Saxenda make my pill less effective? ▾
Most Diabetes Treatment medications at 6 mg/mL do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Liraglutide states whether the interaction is meaningful.
Do I need a backup contraceptive on Saxenda? ▾
Backup contraception is needed only when there is a documented interaction between Saxenda and the contraceptive method. For most users at 6 mg/mL, no backup is required. The pharmacist confirms whether Liraglutide interacts with hormonal contraception.
More on Saxenda
- With alcoholSaxenda and alcohol — is it safe to drink?
- With foodShould Saxenda be taken with food?
- Side effectsSaxenda side effects: common, rare and warning signs
- Dosage guideSaxenda dosage guide: how much to take and when
- OnsetHow fast does Saxenda start working?
- DurationHow long does Saxenda last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.